Inter-epitope spacer variation within polytopic L2-based human papillomavirus antigens affects immunogenicity

Abstract The human papillomavirus minor capsid protein L2 is being extensively explored in pre-clinical studies as an attractive vaccine antigen capable of inducing broad-spectrum prophylactic antibody responses. Recently, we have developed two HPV vaccine antigens – PANHPVAX and CUT-PANHPVAX- both...

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Autori principali:	Yueru Zhang, Filipe Colaco Mariz, Peter Sehr, Gloria Spagnoli, Karl Moritz Koenig, Simay Çelikyürekli, Tim Kreuziger, Xueer Zhao, Angelo Bolchi, Simone Ottonello, Martin Müller
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-02-01
Serie:	npj Vaccines
Accesso online:	https://doi.org/10.1038/s41541-024-00832-0
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