Options to Improve the Action of PROTACs in Cancer: Development of Controlled Delivery Nanoparticles

Classical targeting in cancer focuses on the development of chemical structures able to bind to protein pockets with enzymatic activity. Some of these molecules are designed to bind the ATP side of the kinase domain avoiding protein activation and the subsequent oncogenic activity. A further improve...

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Autores principales:	Alberto Juan, María del Mar Noblejas-López, María Arenas-Moreira, Carlos Alonso-Moreno, Alberto Ocaña
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2022-02-01
Colección:	Frontiers in Cell and Developmental Biology
Materias:	PROTACs technology drug delivery systems nanomedicine polymeric nanoparticles lipid-based nanoparticles metallic nanoparticles
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fcell.2021.805336/full
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