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Inhibition of colorectal cancer progression through conformation-specific targeting of ADAM10 metalloprotease

IntroductionColorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Current first- and second-line therapies rely on oxaliplatin- or irinotecan-based combination chemotherapies combined with antibody-mediated inhibition of EGFR- or VEGF-dependent signaling, but these...

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Autori principali: Pargol Mashati, Dan Sun, Eduardo Garcia Reino, Giuseppe Militello, Nicholas Gao, Jessica A. Blandino, Nayanendu Saha, Dimitar B. Nikolov, Prem K. Premsrirut
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-01-01
Serie:Frontiers in Oncology
Soggetti:
ADAM10
colorectal cancer
EGFR
invasion
Notch
proliferation
Accesso online:https://www.frontiersin.org/articles/10.3389/fonc.2025.1704436/full
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