Endolysosomal trafficking regulator SH-BC-893 inhibits coronavirus entry in vitro and in vivo

Abstract SARS-CoV-2 vaccination or infection may not protect from future novel coronavirus outbreaks. Although several drugs targeting essential coronavirus proteins are broadly effective, the error-prone coronavirus RNA-dependent RNA polymerase and a rapid viral replication cycle mean that drug res...

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Auteurs principaux:	Brendan T. Finicle, Arielle S. Perrochon, Brandon Chu, Michael J. Buchmeier, Aimee L. Edinger
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2026-05-01
Collection:	Scientific Reports
Sujets:	Coronavirus SARS-CoV-2 Host-targeted anti-viral Endolysosomal trafficking PIKfyve inhibitor MHV-1
Accès en ligne:	https://doi.org/10.1038/s41598-026-51335-y
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