iPepGen: a modular, immunopeptidogenomic analysis pipeline for discovery, verification, and prioritization of cancer peptide neoantigen candidates

Abstract Characterizing tumor-specific neoantigen peptides, derived from genomic or transcriptomic aberrations and presented to the immune system, is critical for immuno-oncology studies. To this end, the modular iPepGen immunopeptidogenomics pipeline provides these functions: (1) Neoantigen predict...

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Hlavní autoři:	Subina Mehta, Reid Wagner, Katherine T. Do, James E. Johnson, Fengchao Yu, Tyler Jubenville, Kyle Richards, Suzanne Coleman, Flavia E. Popescu, Alexey I. Nesvizhskii, David A. Largaespada, Pratik D. Jagtap, Timothy J. Griffin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-02-01
Edice:	Genome Biology
Témata:	Neoantigen Immunopeptidomics Immuno-oncology Mass spectrometry Next-generation sequencing Multi-omics
On-line přístup:	https://doi.org/10.1186/s13059-026-04012-2
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