Benzofuran-isatin derivative 5d acts as a dual-action agent in colorectal cancer cells by targeting EMT and mitochondrial apoptosis pathways

Objective: To investigate the anticancer effects of a novel benzofuran-isatin conjugate [N’-(5-methoxy-2-oxoindolin-3-ylidene)-3-methylbenzofuran-2-carbohydrazide (conjugate 5d)] against human colorectal adenocarcinoma (CRC) HT29 and metastatic SW620 colorectal cancer cells. Methods: The cytotoxic p...

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Detalhes bibliográficos

Principais autores:	Maha Hamadien Abdulla, Mansoor-Ali Vaali-Mohammed, Sabine Matou Nasri, Noura S. Alhassan, M. Meeramaideen, Abdullah Al Obeed, Wagdy M. Eldehna, Rofaida Salem, Thamer Traiki, Khayal Al Khayal
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wolters Kluwer Medknow Publications 2026-05-01
coleção:	Asian Pacific Journal of Tropical Biomedicine
Assuntos:	colorectal cancer synthetic benzofuranisatin conjugate apoptosis cell cycle anticancer epithelialmesenchymal transition
Acesso em linha:	https://journals.lww.com/10.4103/apjtb.apjtb_408_25
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