Three-component Castagnoli-Cushman reaction with ammonium acetate delivers 2-unsubstituted isoquinol-1-ones as potent inhibitors of poly(ADP-ribose) polymerase (PARP)

An earlier described three-component variant of the Castagnoli-Cushman reaction employing homophthalic anhydrides, carbonyl compound and ammonium acetate was applied towards the preparation of 1-oxo-3,4-dihydroisoquinoline-4-carboxamides with variable substituent in position 3. These compounds displ...

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Autori principali:	Alexander Safrygin, Petr Zhmurov, Dmitry Dar’in, Sergey Silonov, Mariia Kasatkina, Yulia Zonis, Maxim Gureev, Mikhail Krasavin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2021-01-01
Serie:	Journal of Enzyme Inhibition and Medicinal Chemistry
Soggetti:	castagnoli-cushman reaction 1-oxo-3,4-dihydroisoquinoline-4-carboxamides poly(adp-ribose) polymerase parp1/2 selectivity nad+ mimetics druglikeness
Accesso online:	http://dx.doi.org/10.1080/14756366.2021.1969386
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