In-Silico Screening of Novel Synthesized Thienopyrimidines Targeting Fms Related Receptor Tyrosine Kinase-3 and Their In-Vitro Biological Evaluation

The present investigation describes the design strategy and synthesis of novel thienopyrimidine compounds in addition to their anticancer activity targeting tyrosine kinase FLT3 enzyme. The synthesized compounds were subjected to a cytotoxic study where compounds <b>9a</b> and <b>9b</b> showed the m...

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Bibliografische Detailangaben

Hauptverfasser:	Elshaymaa I. Elmongy, Najla Altwaijry, Nashwah G. M. Attallah, Manal Mubarak AlKahtani, Hanan Ali Henidi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-01-01
Schriftenreihe:	Pharmaceuticals
Schlagworte:	thienopyrimidines selectivity index in-silico screening tyrosine kinase enzyme
Online-Zugang:	https://www.mdpi.com/1424-8247/15/2/170
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