The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity

Abstract Background The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown,...

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Autores principales:	Bernhard Moser, Bernhard Hochreiter, José Basílio, Viola Gleitsmann, Anja Panhuber, Alan Pardo-Garcia, Bastian Hoesel, Manuel Salzmann, Ulrike Resch, Mamoona Noreen, Johannes A. Schmid
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2021-01-01
Colección:	Molecular Cancer
Materias:	c-Myc IKKα NF-κB Cancer Inflammation
Acceso en línea:	https://doi.org/10.1186/s12943-021-01308-8
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