Amyloid Phenotype Characterization of Transgenic Mice Overexpressing both Mutant Amyloid Precursor Protein and Mutant Presenilin 1 Transgenes

Doubly transgenic mice (PSAPP) overexpressing mutant APP and PS1 transgenes were examined using antibodies to Aβ subtypes and glial fibrillary acidic protein (GFAP). Visible Aβ deposition began primarily in the cingulate cortex of PSAPP mice at approximately 10 weeks of age. By 6 months, the mice ha...

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Detalhes bibliográficos

Principais autores:	E. McGowan, S. Sanders, T. Iwatsubo, A. Takeuchi, T. Saido, C. Zehr, X. Yu, S. Uljon, R. Wang, D. Mann, D. Dickson, K. Duff
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 1999-08-01
coleção:	Neurobiology of Disease
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996199902437
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