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Abnormalities of the endocannabinoid system produce piercing nuclear hernias in migrating cerebral neurons

Summary: We are reporting powerful streams of chromatin rupturing the nuclear envelope (NE) and the plasma membrane of migrating cerebral neurons in mouse embryos, which we suggest naming “piercing nuclear hernia” (PNH). About 40% of migrating neurons in cannabinoid type 1 receptor knock-out (CB1R−/...

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Principais autores: Yury M. Morozov, Pasko Rakic
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2025-08-01
Serija:iScience
Teme:
Online dostop:http://www.sciencedirect.com/science/article/pii/S258900422501449X
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