Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria

Changes in the phenylalanine (PHE)/tyrosine (TYR) pathway metabolites before and during homogentisic acid (HGA)-lowering by nitisinone in the Suitability of Nitisinone in Alkaptonuria (AKU) 2 (SONIA 2) study enabled the magnitude of the flux in the pathway to be examined. SONIA 2 was a 48-month rand...

Description complète

Détails bibliographiques

Auteurs principaux:	Lakshminarayan R. Ranganath, Andrew T. Hughes, Andrew S. Davison, Milad Khedr, Richard Imrich, Mattias Rudebeck, Birgitta Olsson, Brendan P. Norman, George Bou-Gharios, James A. Gallagher, Anna M. Milan
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-09-01
Collection:	Metabolites
Sujets:	alkaptonuria pigment biliary excretion ochronosis nitisinone homogentisic acid
Accès en ligne:	https://www.mdpi.com/2218-1989/12/10/920
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!