Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen

Summary: This study investigates the efficacy of proteomic analysis of human remains to identify active infections in the past through the detection of pathogens and the host response to infection. We advance leprosy as a case study due to the sequestering of sufferers in leprosaria and the suggesti...

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Detalhes bibliográficos

Principais autores:	Shevan Wilkin, Liam T. Lanigan, Nuria Montes, Mukul Sharma, Charlotte Avanzi, Donikë Sejdiu, Kerttu Majander, Saskia Pfrengle, Yun Chiang, Laura Kunz, Antje Dittmann, Frank Rühli, Pushpendra Singh, Maria Fontanals Coll, Matthew J. Collins, Alberto J. Taurozzi, Verena J. Schuenemann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-05-01
coleção:	iScience
Assuntos:	Biochemistry Biochemistry applications Biochemistry methods Medical biochemistry Proteomics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S258900422400885X
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