Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges

Abstract We previously developed a temperature-sensitive, and NS1 gene deleted live attenuated influenza vaccine (DelNS1-LAIV) and demonstrated its potent protective efficacy in intranasally vaccinated mice. Here we investigated whether intradermal (i.d.) vaccination induces protective immunity. Our...

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Autors principals:	Andrew Chak-Yiu Lee, Anna Jinxia Zhang, Can Li, Yanxia Chen, Feifei Liu, Yan Zhao, Hin Chu, Carol Ho-Yan Fong, Pui Wang, Siu-Ying Lau, Kelvin Kai-Wang To, Honglin Chen, Kwok-Yung Yuen
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2021-08-01
Col·lecció:	npj Vaccines
Accés en línia:	https://doi.org/10.1038/s41541-021-00359-8
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