Novel Artificial 5′UTR Increase Modified mRNA Translation When Injected into Mouse Heart

<b>Background/Objectives:</b> Modified messenger RNA (modRNA) is a promising gene delivery method used to upregulate genes in cardiac tissue, with applications in both clinical and preclinical settings to prevent cardiac remodeling after ischemic injury. The 5′ untranslated region (5′UTR) plays a cr...

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Bibliografiske detaljer

Principais autores:	Ann Anu Kurian, Matteo Ghiringhelli, Eyal Shalom, Gayatri Mainkar, Magdalena M. Żak, Matthew Adjmi, Jeffrey Downey, Seonghun Yoon, Nicole Dubois, Filip K. Swirski, Lior Zangi
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2025-04-01
Serier:	Pharmaceutics
Fag:	modified RNA (modRNA) 5′ untranslated region cardiac gene therapy translation efficiency synthetic RNA motif
Online adgang:	https://www.mdpi.com/1999-4923/17/4/490
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