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Rescued Chondrogenesis of Mesenchymal Stem Cells under Interleukin 1 Challenge by Foamyviral Interleukin 1 Receptor Antagonist Gene Transfer

Background: Mesenchymal stem cells (MSCs) and their chondrogenic differentiation have been extensively investigated in vitro as MSCs provide an attractive source besides chondrocytes for cartilage repair therapies. Here we established prototype foamyviral vectors (FVV) that are derived from apathoge...

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Principais autores: Nicole Armbruster, Jennifer Krieg, Manuel Weißenberger, Carsten Scheller, Andre F. Steinert
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017-05-01
Serier:Frontiers in Pharmacology
Fag:
mesenchymal stem cell
chondrogenesis
pellet culture
foamy virus
virus vectors
IL1RA
Online adgang:http://journal.frontiersin.org/article/10.3389/fphar.2017.00255/full
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