Therapeutic drug monitoring of phenytoin and valproic acid in critically ill patients at Windhoek Central Hospital, Namibia

Background: Phenytoin and valproic acid, anticonvulsants, have a low therapeutic index and are highly plasma protein bound, mainly to albumin. Hypoalbuminaemia is common in critically ill patients and increases the unbound drug concentration. Thus, monitoring unbound rather than total plasma drug co...

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Principais autores:	Bonifasius S. Singu, Helen Morrison, Lydia Irengeya, Roger K. Verbeeck
Format:	Artigo
Jezik:	Inglês
Izdano:	AOSIS 2022-07-01
Serija:	African Journal of Laboratory Medicine
Teme:	phenytoin valproic acid critically ill patients therapeutic drug monitoring unbound concentration
Online dostop:	https://ajlmonline.org/index.php/ajlm/article/view/1628
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