CD4+ T-Cells With High Common γ Chain Expression and Disturbed Cytokine Production Are Enriched in Children With Type-1 Diabetes

The common gamma chain (γc) contributes to the formation of different cytokine receptors [e.g., IL-2 receptor (IL-2R), IL-7R, and IL-15R], which are important for generation of self-reactive T-cells in autoimmune diseases, like in type 1 diabetes (T1D). Whereas, the roles of membrane and soluble IL-...

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Autori principali:	Julia Seyfarth, Nathalie Mütze, Jennifer Antony Cruz, Sebastian Kummer, Christina Reinauer, Ertan Mayatepek, Thomas Meissner, Marc Jacobsen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2019-04-01
Serie:	Frontiers in Immunology
Soggetti:	biomarker immunology common gamma chain interleukin-2 interleukin-7 type 1 diabetes
Accesso online:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00820/full
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