Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

Abstract Background A pair of genes is defined as synthetically lethal if defects on both cause the death of the cell but a defect in only one of the two is compatible with cell viability. Ideally, if A and B are two synthetic lethal genes, inhibiting B should kill cancer cells with a defect on A, a...

Descripció completa

Dades bibliogràfiques

Autors principals:	Pietro Pinoli, Sriganesh Srihari, Limsoon Wong, Stefano Ceri
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2021-05-01
Col·lecció:	BMC Bioinformatics
Matèries:	Synthetic lethality Copy number alteration DNA damage repair genes
Accés en línia:	https://doi.org/10.1186/s12859-021-04168-7
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!