Comparable Bioavailability and Disposition of Pefloxacin in Patients with Cystic Fibrosis and Healthy Volunteers Assessed via Population Pharmacokinetics

Quinolone antibiotics present an attractive oral treatment option in patients with cystic fibrosis (CF). Prior studies have reported comparable clearances and volumes of distribution in patients with CF and healthy volunteers for primarily renally cleared quinolones. We aimed to provide the first ph...

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Hlavní autoři:	Jürgen B. Bulitta, Yuanyuan Jiao, Cornelia B. Landersdorfer, Dhruvitkumar S. Sutaria, Xun Tao, Eunjeong Shin, Rainer Höhl, Ulrike Holzgrabe, Ulrich Stephan, Fritz Sörgel
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2019-07-01
Edice:	Pharmaceutics
Témata:	cystic fibrosis patients healthy volunteers fluoroquinolone pefloxacin absolute bioavailability population pharmacokinetics allometric scaling body size body composition S-ADAPT
On-line přístup:	https://www.mdpi.com/1999-4923/11/7/323
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