Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing

Oligonucleotides (ONs) have been envisaged for therapeutic applications for more than thirty years. However, their broad use requires overcoming several hurdles such as instability in biological fluids, low cell penetration, limited tissue distribution, and off-target effects. With this aim, many ch...

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Detalhes bibliográficos

Principais autores:	Françoise Debart, Christelle Dupouy, Jean-Jacques Vasseur
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Beilstein-Institut 2018-02-01
coleção:	Beilstein Journal of Organic Chemistry
Assuntos:	enzymolabile group light-responsive group oligonucleotide prodrugs reduction-responsive stimuli-responsive nucleic acids thermolytic prodrugs
Acesso em linha:	https://doi.org/10.3762/bjoc.14.32
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