Molecular mechanism of the wake-promoting agent TAK-925
Abstract The OX2 orexin receptor (OX2R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in humans. Antagonism of OX2R is a proven therapeutic strategy for insomnia drugs, and agonism of OX2R is a potentially powerful approach for...
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| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Portfolio
2022-05-01
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| Colección: | Nature Communications |
| Acceso en línea: | https://doi.org/10.1038/s41467-022-30601-3 |
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