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Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach

Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved isoforms in mammals: FLNA, FLNB, and FLNC. FLNB is a multidomain monomer prot...

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Principais autores: Udhaya Kumar S., Srivarshini Sankar, Salma Younes, Thirumal Kumar D., Muneera Naseer Ahmad, Sarah Samer Okashah, Balu Kamaraj, Abeer Mohammed Al-Subaie, George Priya Doss C., Hatem Zayed
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-11-01
coleção:Molecules
Assuntos:
FLNB
CH2 domain
Larsen syndrome
boomerang dysplasia
atelosteogenesis type I
molecular dynamics simulation (MDS)
Acesso em linha:https://www.mdpi.com/1420-3049/25/23/5543
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