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NUPR1 as a central stress-adaptation node in cancer: integrating metabolic rewiring, cell death, and therapy resistance

Abstract Nuclear protein 1 (NUPR1) is an intrinsically disordered, stress-adaptive regulator that sits at the intersection of transcriptional plasticity and proteostatic control, broadly upregulated across malignancies and tightly associated with poor prognosis. Here, we synthesize evidence position...

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Hauptverfasser: Tanqing Long, Qi Wang, Yinpeng Le, Mi Zhang, Yan Sun, Juan Iovanna, Lei Li, Chuanrui Xu, Juan Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-05-01
Schriftenreihe:Journal of Biomedical Science
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Online-Zugang:https://doi.org/10.1186/s12929-026-01254-x
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