The myeloid SRC family kinase HCK regulates breast cancer growth by activating tumor-associated macrophage-led invasion and inhibiting cytotoxic T cell activity

IntroductionThe normal developmental and homeostatic roles of tissue resident macrophages are subverted in tumor-associated macrophages to promote tumor progression. Pro-tumoral macrophage activities include immune suppression and promotion of invasion and metastasis. While the myeloid Src family ki...

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Principais autores:	Michael W. Murrey, Ashleigh R. Poh, James H. Steer, Catherine Rinaldi, Kellie A. Mouchemore, Amy R. Dwyer, Elena Denisenko, Irina Kuznetsova, Yen Yeow, Matthew E. Jones, Khaing P. W. Hmon, Dáithí Ó Muirí, Ya-Yu Liu, Weitao Lin, Alistair R. R. Forrest, Lesley G. Ellies, David A. Joyce, Matthias Ernst, Fiona J. Pixley
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-02-01
Series:	Frontiers in Immunology
Assuntos:	breast cancer cytotoxic T cells HCK tumor invasion tumor-associated macrophages
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1709102/full
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