DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

Abstract Background A key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target difference between the treatments for the primary outcome and then calculate the required sample size. The sample size is chosen...

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Autors principals:	Jonathan A. Cook, Steven A. Julious, William Sones, Lisa V. Hampson, Catherine Hewitt, Jesse A. Berlin, Deborah Ashby, Richard Emsley, Dean A. Fergusson, Stephen J. Walters, Edward C. F. Wilson, Graeme Maclennan, Nigel Stallard, Joanne C. Rothwell, Martin Bland, Louise Brown, Craig R. Ramsay, Andrew Cook, David Armstrong, Doug Altman, Luke D. Vale
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2018-11-01
Col·lecció:	Trials
Accés en línia:	http://link.springer.com/article/10.1186/s13063-018-2884-0
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