Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla.
The thymic medulla is dedicated for purging the T-cell receptor (TCR) repertoire of self-reactive specificities. Medullary thymic epithelial cells (mTECs) play a pivotal role in this process because they express numerous peripheral tissue-restricted self-antigens. Although it is well known that medu...
Tallennettuna:
| Päätekijät: | , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science (PLoS)
2012-01-01
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| Sarja: | PLoS ONE |
| Linkit: | http://europepmc.org/articles/PMC3531460?pdf=render |
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