Hypoxia-preconditioned mesenchymal stromal cell–derived exosomes attenuate LPS-induced acute lung injury and early epithelial remodeling in mice: evidence for a miR-486a-5p–Skp2–GATA4 axis

Abstract Background Acute lung injury (ALI) can initiate early epithelial remodeling that may precede pulmonary fibrosis, with EMT of alveolar epithelial cells implicated in this acute phase. While mesenchymal stromal cell (MSC)-derived exosomes exhibit repair potential, their conventional culture c...

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Egile Nagusiak:	Qun Lin, Siling Zou, Can Lin, Jun Lin, Yanlin Wu, Rifeng Liu, Lihua Lei
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2026-02-01
Saila:	Respiratory Research
Gaiak:	Exosomes Hypoxia Acute lung injury EMT miR-486a-5p Skp2
Sarrera elektronikoa:	https://doi.org/10.1186/s12931-026-03560-2
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