Hydrophobic interaction chromatography resolves extracellular vesicle fractions with distinct lipidomic signatures

Abstract Current extracellular vesicle (EV) isolation workflows are dominated by size- and density-based approaches, which provide limited insight into surface chemical properties of vesicular particles. Here, we report a hydrophobic interaction chromatography (HIC) workflow for resolving EV fractio...

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Detalhes bibliográficos

Principais autores:	Michał Młynarczyk, Wiktoria Więckowska, Mariusz Belka, Raphael Ewonde Ewonde, Jagoda Mantej, Mikołaj Klimczuk, Felicja Gajdowska, Jorge Matinha-Cardoso, Paula Tamagnini, Danuta Gutowska-Owsiak, Paulo Oliveira, Sebastiaan Eeltink, Weronika Hewelt-Belka
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-05-01
coleção:	Scientific Reports
Assuntos:	Hydrophobic interaction chromatography (HIC) Extracellular vesicle Lipidomics Surface hydrophobicity Human milk extracellular vesicles
Acesso em linha:	https://doi.org/10.1038/s41598-026-50782-x
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