Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid[S]

X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by impaired degradation of very long-chain fatty acids (VLCFAs) due to mutations in the ABCD1 gene responsible for VLCFA transport into peroxisomes. Lorenzo's oil, a 4:1 mixture of glyceryl trioleate and glyceryl trierucate, has...

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Autores principales:	Takayuki Sassa, Takeshi Wakashima, Yusuke Ohno, Akio Kihara
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2014-03-01
Colección:	Journal of Lipid Research
Materias:	ABCD1 erucic acid oleic acid peroxisome sphingolipids X-linked adrenoleukodystrophy
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0022227520376859
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