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FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia

Abstract Background Spastin significantly influences microtubule regulation in neurons and is implicated in the pathogenesis of hereditary spastic paraplegia (HSP). However, post-translational regulation of the spastin protein remains nebulous. The association between E3 ubiquitin ligase and spastin...

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Bibliografiske detaljer
Principais autores: Hyun Mi Kang, Dae Hun Kim, Mijin Kim, Yoohong Min, Bohyeon Jeong, Kyung Hee Noh, Da Yong Lee, Hyun-Soo Cho, Nam-Soon Kim, Cho-Rok Jung, Jung Hwa Lim
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-07-01
Serier:Cell & Bioscience
Fag:
Online adgang:https://doi.org/10.1186/s13578-022-00851-1
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