4-Oxo-2-Nonenal- and Agitation-Induced Aggregates of α-Synuclein and Phosphorylated α-Synuclein with Distinct Biophysical Properties and Biomedical Applications

α-Synuclein (α-syn) can form oligomers, protofibrils, and fibrils, which are associated with the pathogenesis of Parkinson’s disease and other synucleinopathies. Both the lipid peroxidation product 4-oxo-2-nonenal (ONE) and agitation can induce aggregation of α-syn and phosphorylated α-syn. Thus, cl...

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Autori principali:	Tie Wang, Weijin Liu, Qidi Zhang, Jie Jiao, Zihao Wang, Ge Gao, Hui Yang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2024-04-01
Serie:	Cells
Soggetti:	α-synuclein 4-oxo-2-nonenal (ONE) aggregates preformed fibrils (PFF) phosphorylation enzyme-linked immunosorbent assay
Accesso online:	https://www.mdpi.com/2073-4409/13/9/739
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