HIV-1 Nef activates proviral DNA transcription by recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive function

ABSTRACT HIV-1 accessory protein Nef is a multifunctional pathogenic factor that mediates immune evasion, enhances virion infectivity, antagonizes host restrictive factors, and promotes viral dissemination. However, the modulation of Nef on proviral DNA transcription of latently infected viruses is...

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Auteurs principaux:	Tian-Jiao Fan, Chengzuo Xie, Lisha Li, Xia Jin, Jie Cui, Jian-Hua Wang
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2025-05-01
Collection:	Journal of Virology
Sujets:	HIV Nef Nef-associated factor 1 proviral transcription
Accès en ligne:	https://journals.asm.org/doi/10.1128/jvi.00280-25
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