Structural principles of insulin formulation and analog design: A century of innovation

Background: The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the stabilization of animal insulin formulations to the frontiers of synthetic peptide chemistry, and in turn, from the advent of recombina...

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Auteurs principaux:	Mark A. Jarosinski, Balamurugan Dhayalan, Yen-Shan Chen, Deepak Chatterjee, Nicolás Varas, Michael A. Weiss
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2021-10-01
Collection:	Molecular Metabolism
Sujets:	Protein engineering Pharmacodynamics Insulin action Insulin signaling Molecular pharmacology
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2212877821001721
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