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IFNL4-rs12979860 CC genotype predisposes to accelerated terminal exhaustion and senescence in HIV/HCV-chronic infection

Abstract Purpose rs12979860 polymorphism of the lambda 4 interferon (IFNL4) gene has been related with Hepatitis C Virus (HCV) spontaneous clearance (CC genotype favourable versus CT/TT). The implications of this polymorphism over chronic-HCV disease are unknown, particularly during Human Immunodefi...

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Principais autores: Sonia Arca-Lafuente, Violeta Lara-Aguilar, Manuel Llamas-Adán, Sergio Grande-García, Andrés Deza de la Casa, Luz Martín-Carbonero, Pablo Ryan, Ignacio de los Santos, Mariano Matarranz, Mª Ángeles Jiménez-Sousa, Amanda Fernández-Rodríguez, Verónica Briz
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2025-12-01
Series:Journal of Translational Medicine
Assuntos:
HCV/HIV
INFL4
CC-genotype
Senescence
CD4+ T cells
CD8+ T cells
Acceso en liña:https://doi.org/10.1186/s12967-025-07070-5
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