Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

L-type amino acid transporter 1 (LAT1) is known as a cancer-type amino acid transporter. In cancer cells, LAT1 is responsible for the cellular uptake of many essential amino acids including leucine that activates mechanistic/mammalian target of rapamycin (mTOR), regulating cancer cell growth. In thi...

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Detalhes bibliográficos

Principais autores:	Pornparn Kongpracha, Shushi Nagamori, Pattama Wiriyasermkul, Yoko Tanaka, Kazuko Kaneda, Suguru Okuda, Ryuichi Ohgaki, Yoshikatsu Kanai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-02-01
coleção:	Journal of Pharmacological Sciences
Assuntos:	L-type amino acid transporter 1 (LAT1) Inhibitor Structure-activity relationship Anti-cancer agent
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1347861317300142
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