Repression of factor VIII inhibitor development with apoptotic factor VIII-expressing embryonic stem cells

Development of factor VIII (fVIII)-neutralizing antibodies, called inhibitors, is a challenging problem in the management of hemophilia A patients. We explored the possibility of pretreatment with apoptotic fVIII-expressing embryonic stem (ES) cells to prevent the development of fVIII inhibitors. Mu...

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Autori principali:	Yoshihiko Sakurai, Shogo Kasuda, Kohei Tatsumi, Tomohiro Takeda, Junko Kato, Atsushi Kubo, Midori Shima
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2013-07-01
Serie:	Hematology Reports
Soggetti:	hemophilia, fVIII inhibitors, prevention, embryonic stem cells, apoptosis
Accesso online:	http://www.pagepress.org/journals/index.php/hr/article/view/4461
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