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Teriflunomide and Epstein–Barr virus in a Spanish multiple sclerosis cohort: in vivo antiviral activity and clinical response

BackgroundEpstein–Barr virus (EBV) and human herpesvirus 6 (HHV-6) have been associated with multiple sclerosis (MS). Teriflunomide is an oral disease-modifying therapy approved for treatment of relapsing forms of MS. In the preclinical Theiler’s murine encephalitis virus model of MS, the drug demon...

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Principais autores: María Inmaculada Domínguez-Mozo, Inés González-Suárez, Luisa María Villar, Lucienne Costa-Frossard, Noelia Villarrubia, Yolanda Aladro, Belén Pilo, Xavier Montalbán, Manuel Comabella, Ignacio Casanova-Peño, María Luisa Martínez-Ginés, Jose Manuel García-Domínguez, María Ángel García-Martínez, Rafael Arroyo, Roberto Álvarez-Lafuente
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-09-01
Serier:Frontiers in Immunology
Fag:
multiple sclerosis
teriflunomide
biomarker
EDSS
EBV
HHV-6
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1248182/full
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