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Influence of Voxelotor–hemoglobin complexes in the estimation of hemoglobin S levels by the current standard of care laboratory evaluation techniques

BackgroundSickle cell disease is an inherited disorder characterized by the presence of sickle hemoglobin (HbS). The process of Hb molecule polymerization is a pivotal step in the sickling process. Voxelotor, a recently approved novel therapeutic agent, is known to interfere with polymerization. We...

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Principais autores: Salam Alkindi, Ahmed Al Subhi, Abubakr E. H. Ali, Anil V. Pathare
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-04-01
coleção:Frontiers in Medicine
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Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmed.2023.1149281/full
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