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Increased Brown Adipose Tissue Thermogenesis in Phenylketonuria

ABSTRACT Phenylketonuria (PKU), the most common autosomal‑recessive disorder of amino acid metabolism, is characterized by neurological impairment and systemic metabolic alterations caused by chronically elevated phenylalanine (Phe) levels. PKU patients have long been reported to display reduced met...

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Autori principali: Noemí López‐Rey, Alba Cabaleiro, María P. Pata, Marion Peyrou, Ánxela Estévez‐Salguero, Paola Fernández‐Sanmartín, Donald A. Morgan, Vitor Ferreira, Paula Sánchez‐Pintos, Cintia Folgueira, Carlos Diéguez, Adela Urisarri, Ismael González‐García, Luisa M. Seoane, Kamal Rahmouni, Francesc Villarroya, María L. Couce, Rubén Nogueiras, Miguel López
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2026-06-01
Serie:MedComm
Soggetti:
AMP‑activated protein kinase (AMPK)
brown adipose tissue (BAT)
fibroblast growth factor 21 (FGF21)
hypothalamus
phenylketonuria (PKU)
thyroid hormones (THs)
Accesso online:https://doi.org/10.1002/mco2.70820
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