Mislocalisation of FLT3-ITD receptor contributes to MV4-11 leukaemia cell resistance to antibody-drug conjugate

FMS-like tyrosine kinase 3 (FLT3/CD135) regulates haematopoiesis and is frequently mutated as FLT3-internal tandem duplication (FLT3-ITD) in acute myeloid leukaemia (AML), associated with poor prognosis. Although FLT3 inhibitors show clinical benefits, resistance remains a challenge. This study hypo...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Wariya Nirachonkul, Mark P. Farrell, Thomas J. Tolbert, Siriporn Okonogi, Singkome Tima, Songyot Anuchapreeda, Sawitree Chiampanichayakul, Teruna J. Siahaan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2026-12-01
Edice:	Journal of Enzyme Inhibition and Medicinal Chemistry
Témata:	FLT3-internal tandem duplication (FLT3-ITD) antibody-drug conjugates (ADCs) acute myeloblastic leukaemia (AML) MV4-11 FLT3-MMAE conjugate
On-line přístup:	https://www.tandfonline.com/doi/10.1080/14756366.2026.2638027
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!