The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

Abstract Background Loss-of-function mutations of ZBTB24 cause immunodeficiency, centromeric instability, and facial anomalies syndrome 2 (ICF2). ICF2 is a rare autosomal recessive disorder with immunological defects in serum antibodies and circulating memory B cells, resulting in recurrent and some...

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Bibliografiske detaljer

Principais autores:	He Gao, Ying Zhao, Sai Zhao, Xiao-Qiu Dai, Xiao-Yuan Qin, Wei-Long Zheng, Ting-Ting He, Nan Zhang, Can Zhu, Hong-Min Wang, Wen Pan, Xue-Mei Zhu, Xiao-Ming Gao, Jian-Feng Dai, Fang-Yuan Gong, Jun Wang
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2024-09-01
Serier:	Cellular & Molecular Biology Letters
Fag:	ICF2 Zbtb24 B1 cells Plasma cell differentiation Heme synthesis
Online adgang:	https://doi.org/10.1186/s11658-024-00641-2
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