Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types.

Gene fusions, like BCR/ABL1 in chronic myelogenous leukemia, have long been recognized in hematologic and mesenchymal malignancies. The recent finding of gene fusions in prostate and lung cancers has motivated the search for pathogenic gene fusions in other malignancies. Here, we developed a "breakp...

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Detalhes bibliográficos

Principais autores:	Craig P Giacomini, Steven Sun, Sushama Varma, A Hunter Shain, Marilyn M Giacomini, Jay Balagtas, Robert T Sweeney, Everett Lai, Catherine A Del Vecchio, Andrew D Forster, Nicole Clarke, Kelli D Montgomery, Shirley Zhu, Albert J Wong, Matt van de Rijn, Robert B West, Jonathan R Pollack
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2013-04-01
coleção:	PLoS Genetics
Acesso em linha:	http://europepmc.org/articles/PMC3636093?pdf=render
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