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A specific stem cell program and CD112 immunological axis dysfunctions underpinning monosomy 7-associated myeloid neoplasms

Abstract Monosomy 7 (−7) is occurring as isolated change or in complex karyotypes in 10–20% of myeloid neoplasms with poor prognosis. Although several genes mapping at chromosome 7 have been involved in pathogenetic mechanisms, the −7 molecular landscape is not fully elucidated. Using an epi-transcr...

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I tiakina i:
Ngā kaituhi matua: Anair Graciela Lema Fernandez, Carlotta Nardelli, Martina Quintini, Valeria Di Battista, Valentina Pierini, Barbara Crescenzi, Fabrizia Pellanera, Caterina Matteucci, Valentina Bardelli, Maria Crocioni, Giovanni Martino, Francesco Maria Adamo, Francesca Milano, Maria Paola Martelli, Pietro Merli, Loredana Bury, Paolo Gorello, Mattia Forcato, Franco Locatelli, Loredana Ruggeri, Cristina Mecucci
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Publishing Group 2026-05-01
Rangatū:Signal Transduction and Targeted Therapy
Urunga tuihono:https://doi.org/10.1038/s41392-026-02681-w
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