Tier-specific location of Lewy body pathology and related neuromelanin levels drive dopaminergic cell vulnerability in pigmented non-human primates

ABSTRACT: Although a differential vulnerability of dopaminergic neurons to degeneration based on their specific location within the dorsal and ventral tiers of the substantia nigra pars compacta (SNcD and SNcV, respectively) has long been postulated, the underlying mechanisms sustaining these tier-s...

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Hlavní autoři:	Julia Chocarro, Alberto J. Rico, Goiaz Ariznabarreta, Elena Lorenzo-Ramos, Mario M. Ilarduya, Cristina Canales, Adriana Leon-Villares, Javier Blesa, José A. Obeso, José L. Lanciego
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-09-01
Edice:	Neurobiology of Disease
Témata:	Alpha-synuclein Tyrosinase Substantia nigra Adeno-associated viral vectors Neurodegeneration
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0969996126002585
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