The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity
Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell id...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis Group
2021-11-01
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| Series: | Molecular & Cellular Oncology |
| Assuntos: | |
| Acceso en liña: | http://dx.doi.org/10.1080/23723556.2021.2002120 |
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