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Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection

ABSTRACT Guanine nucleotides are required for growth and viability of cells due to their structural role in DNA and RNA, and their regulatory roles in translation, signal transduction, and cell division. The natural antibiotic mycophenolic acid (MPA) targets the rate-limiting step in de novo guanine...

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Furkejuvvon:
Váldodahkkit: Eric M. Kofoed, Ignacio Aliagas, Terry Crawford, Jialin Mao, Seth F. Harris, Min Xu, Shumei Wang, Ping Wu, Fang Ma, Kevin Clark, Jessica Sims, Yiming Xu, Yutian Peng, Elizabeth Skippington, Ying Yang, Janina Reeder, Savita Ubhayakar, Matt Baumgardner, Zhengyin Yan, Jacob Chen, Summer Park, Hua Zhang, Chun-Wan Yen, Maria Lorenzo, Nicholas Skelton, Xiaorong Liang, Liuxi Chen, Bridget Hoag, Chun Sing Li, Zhiguo Liu, John Wai, Xingrong Liu, Jun Liang, Man Wah Tan
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: American Society for Microbiology 2024-10-01
Ráidu:mBio
Fáttát:
antibiotic target validation
structural biology
Acinetobacter baumannii
bacterial genetics
medicinal chemistry
pharmacology
Liŋkkat:https://journals.asm.org/doi/10.1128/mbio.00897-24
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