LDOC1 connects histone H2B monoubiquitination to tumor cell plasticity in non-small cell lung cancer

Abstract Background Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, partly because epigenetic dysregulation drives tumor progression and metastasis. We previously showed that leucine zipper downregulated in cancer 1 (LDOC1) modulates the metastatic potential o...

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Principais autores:	Hsien-Neng Huang, Pin-Feng Hung, Yi-Ta Tsai, En-Ting Liu, Tai-Lung Cha, Ya-Pin Chen, Wen-Tsan Weng, Chiao-Yin Sun, Wei-Hsuan Yu, Hau-Lun Cheng, Chia-Huei Lee
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-01-01
Series:	Cell Communication and Signaling
Assuntos:	Non-small cell lung cancer (NSCLC) Leucine zipper downregulated in cancer 1 (LDOC1) H2B monoubiquitination (H2Bub1) Epigenetics Epithelial–mesenchymal plasticity Chromatin remodeling
Acceso en liña:	https://doi.org/10.1186/s12964-025-02607-z
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