PhoP- and GlnR-mediated regulation of metK transcription and its impact upon S-adenosyl-methionine biosynthesis in Saccharopolyspora erythraea

Abstract Background Erythromycin A (Er A) has a broad antibacterial effect and is a source of erythromycin derivatives. Methylation of erythromycin C (Er C), catalyzed by S-adenosyl-methionine (SAM)-dependent O-methyltransferase EryG, is the key final step in Er A biosynthesis. Er A biosynthesis, in...

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Autori principali:	Jin-Feng Pei, Yu-Xin Li, Hao Tang, Wenping Wei, Bang-Ce Ye
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2022-06-01
Serie:	Microbial Cell Factories
Soggetti:	Erythromycin A Transcriptional regulation PhoP GlnR SAM
Accesso online:	https://doi.org/10.1186/s12934-022-01846-w
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