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Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice

Summary: Nuclear envelope (NE) ruptures are emerging observations in Lamin-related dilated cardiomyopathy, an adult-onset disease caused by loss-of-function mutations in Lamin A/C, a nuclear lamina component. Here, we test a prevailing hypothesis that NE ruptures trigger the pathological cGAS-STING...

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Wedi'i Gadw mewn:
Prif Awduron: Atsuki En, Hanumakumar Bogireddi, Briana Thomas, Alexis V. Stutzman, Sachie Ikegami, Brigitte LaForest, Omar Almakki, Peter Pytel, Ivan P. Moskowitz, Kohta Ikegami
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2024-06-01
Cyfres:Cell Reports
Pynciau:
nuclear lamina
Lamin A/C
dilated cardiomyopathy
laminopathy
Lmna
cGAS STING
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2211124724006120
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